• br STAR Methods br Acknowledgments

  2021-06-04

  

  STAR★Methods Acknowledgments We thank the City of Hope core facilities, including the Animal Model Core, Bioinformatic Core, NMR Core, Flow Cytometry Core, and Florescence Microscopy Core for excellent technical support, and NIH grants R01GM086171, R01GM102538, and R01CA212119, R01CA216987, a

• It is well known that nanostructured transition metal oxides

  2021-06-04

  

  It is well known that, nanostructured transition metal oxides are the most promising candidates as electrode for pseudocapacitors due to their attractive properties such as environmentally friendly, high theoretical capacitance, low cost and easily abundant [15], [16]. Numerous investigations have b

• Although DGK is a lipid modulating enzyme the role

  2021-06-04

  

  Although DGKγ is a lipid-modulating enzyme, the role of DGKγ in integral cell metabolism has not been reported. We found that DGKγ made a difference on cell metabolism profile in HCC cells, which may be caused partially by the downregulation of GLUT1. Glucose is a major source of energy, and decreas

• br Molecular modeling simulation study Molecular modeling st

  2021-06-04

  

  Molecular modeling simulation study Molecular modeling study was performed through docking of the test compounds into the binding site of hDHFR enzyme using Discovery Studio 2.5 software. Computational docking is an algorithm designed to determine the suitable position and the orientation of the

• This work aimed to investigate whether the increase

  2021-06-03

  

  This work aimed to investigate whether the increase in liver lipid depots, observed in the fetuses from rats fed a saturated-fat-rich diet, persists later in life in the offspring (a) at 21days of age immediately after weaning and (b) at 140days of age, after healthy nourishing. Furthermore, we want

• We also found a significantly inverse correlation of OPRM

  2021-06-03

  

  We also found a significantly inverse correlation of OPRM1 CpG2-4 methylation level with HDL-C in Han male controls. Lipids are known to involve the inflammation pathway, Aβ formation and stability of neuron, whereby their abnormalities have been shown to increase the risk of AD [39], [40], [41]. HD

• feel cold In this study we detected the PAX FOXO fusion gene

  2021-06-03

  

  In this study, we detected the PAX3/7–FOXO1 fusion feel cold in 50% of the ARMS samples, 40% PAX3–FOXO1 and 10% PAX7–FOXO1. This detection confirmed the histological diagnosis and adds to its new information that can be useful in the prognosis evaluation of ARMS patients, since the patients with PAX

• Several questions remain to be addressed The hormones and me

  2021-06-03

  

  Several questions remain to be addressed. The hormones and metabolites that modulate expression of EERγ in the steps leading to maturation need to be identified to learn more about physiological and pathophysiological regulation of EERγ in β cells. Considering that ERRγ repressed cell cycle genes in

• br Role of ERK signaling in preventive

  2021-06-03

  

  Role of ERK signaling in preventive and therapeutic potential of flavonoids in neurodegenerative diseases ERK is one of the main pharmacological targets of natural phenolic compounds and contributes to several therapeutic approaches including anti-atherogenic, anti-cancer, anti-colitis, anti-arth

• Tropical theileriosis is caused by the apicomplexan parasite

  2021-06-03

  

  Tropical theileriosis is caused by the apicomplexan parasite Theileria annulata which is transmitted by a tick vector from the genus Hyalomma in cattle (Echebli et al., 2014, Li et al., 2014). Theileria parasites invade the leukocytes by sporozoites secreted from the vector, schizonts mature into me

• Despite the fact that the precise relevance

  2021-06-03

  

  Despite the fact that the precise relevance of Ube2E self-ubiquitination in vivo is still elusive, findings of Sarkari et al. do establish Ube2E1 ubiquitination in Riluzole [36]. In vivo self-ubiquitination of Ube2E1 is further supported by the high-throughput study aimed to identify all ubiquitina

• RLS is a genetically complex disorder in which genetic

  2021-06-03

  

  RLS is a genetically complex disorder in which genetic and environmental factors contribute to the phenotype (Trenkwalder, Allen, Högl, Paulus, & Winkelmann, 2016). This disease is highly familial and six genetic variants with single nucleotide polymorphisms have been identified by genome-wide assoc

• Compound was advanced to a chronic

  2021-06-02

  

  Compound 52 was advanced to a chronic efficacy study in db/db mice maintained on a high fat diet. Animals were dosed with 0.5% methylcellulose vehicle, Tranexamic Acid 52 (1, 3 or 15mg/kg, po, Q.D.) or 1 (0.3mg/kg) for 14days. Over the course of the study body weight and food intake were measured d

• The present study found a significant negative correlation b

  2021-06-02

  

  The present study found a significant negative correlation between miR-152-3p and CDK8 expression in human HCC tissues. We also validated that CDK8 was a direct target of miR-152-3p, and overexpression of miR-152-3p inhibited proliferation and induced apoptosis in HCC GW-786034 by suppressing CDK8

• To elucidate the potential mechanism underlying

  2021-06-02

  

  To elucidate the potential mechanism underlying osteosarcoma cell growth decrease by CDK4 inhibition, flow cytometry analysis was used to determine Vacuolin-1 and apoptosis in human osteosarcoma cells after palbociclib treatment. The results showed that osteosarcoma cells were arrested in G1 phase

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